This layout is 100% CSS based and can be edited with Dreamweaver, Expression Web, or the editor of your choice. It comes with a dwt file for making global changes. It is also XHTML compliant and includes a fully commented css file.
The download comes with everything you need to set up an online store and you're free to host where you like. The cart set up is well documented and we have a large number of tutorials and help files.